Can You Take Nyquil With High Blood Pressure

Contents

• NyQuil and Robitussin basic facts
• Mechanisms of action – How NyQuil and Robitussin work in the body
  • Can patients take NyQuil and Robitussin together
  • Incidence
  • Side effects
  • Special precautions and warnings during NyQuil and Robitussin administration:
    • Informations retrieved from:

NyQuil and Robitussin basic facts

NyQuil is a brand name for OTC medication which is used for relieving symptoms of mutual cold.

Product is a combination of three active substances: acetaminophen (usually in doses from 325mg to 600mg) used equally a pain reliever and fever reducer, dextromethorphan (usually in doses of 15mg/pill or 30mg/30ml) used equally a cough suppressant, information technology also has allaying properties and doxylamine succinate (usually in doses of half-dozen.25mg/pill or 12.5mg/30ml) which is antihistamine with hypnotic effects that is used in combination with other drugs for relieving symptoms of cold and night-time allergy.

Some Nyquil's preparations can contain other agile substances such as: NyQuil D that contains nasal decongestive pseudoephedrine (30 mg/15 mL), NyQuil Sinus contains phenylephrine as nasal decongestant, Children's NyQuil contains chlorpheniramine as antihistamine and has no alcohol.

NyQuil products on the marketplace are: NyQuil Cold/Influenza Multisymptom Relief, NyQuil D, Children's NyQuil, NyQuil Cough, NyQuil Sinus and ZzzQuil.

Nyquil is bachelor in syrup and and LiquiCap dosage forms. NyQuil contains sedating antihistamines, hypnotics, or alcohol, and that'south why it should be taken before sleep.

Robitussin is a brand proper name for OTC and prescription medications which are used for relieving coughing and cold symptoms.

This Brand name is used for several cough syrup formulations that can contain different active ingredients: acetaminophen (pain reliever and fever reducer found in Robitussin CF), chlorpheniramine (antihistamine found in Robitussin children'southward cough and cold syrups), phenylephrine (decongestant found in Robitussin CF and Daytime Cold + Flu), codeine (narcotic antitussive found in Robitussin DAC and Robitussin Ac), dextromethorphan (non-narcotic antitussive institute in most Robitussin products), diphenhydramine (antihistamine), doxylamine (sleep help), guaifenesin (expectorant establish in well-nigh Robitussin products), promethazine (antihistamine), pseudoephedrine (decongestant) and menthol (oral anesthetic in Robitussin DM lozenges).

Mechanisms of activity – How NyQuil and Robitussin work in the body

Acetaminophen is highly selective COX-2 inhibitor that inhibits prostaglandin synthesis. It tin inhibit COX-2 in CNS. Acetaminophen also acts on the hypothalamic heat regulating centers to produce antipyresis.

Dextromethorphan acts on cough center in medulla by decreasing sensitivity of cough receptors and by interrupting impulse transmission.

Doxylamine succinate is competitor for H1-receptor sites on target cells and also has anticholinergic furnishings, lowering labyrinthine function, blocking chemoreceptor trigger zone, and diminishing vestibular stimulation.

Pseudoephedrine and Phenylephrine are sympathomimetics with direct activity on the adrenergic receptor system. The vasoconstriction is produced after α-adrenergic receptors activation.

Chlorpheniramine is antagonist of histamine H1 receptor (HRH1). It has been too shown that this drug is also a serotonin-norepinephrine reuptake inhibitor.

Guaifenesin acts by reducing the viscosity and increasing the book of secretions in the trachea and bronchi. Studies accept as well shown that guaifenesin has muscle relaxant and anticonvulsant properties due to antagonism furnishings on NMDA receptors.

Can patients take NyQuil and Robitussin together

In that location should be no demand to accept those medications together at the same time every bit they act on the same way, so their furnishings will become condiment and there is a high gamble of serious side effects to happen.

NyQuil and Robitussin, both contain acetaminophen every bit an agile ingredient, and these products are normally taken three-four times a day, so if these preparations are used at the same time, even in recommended daily doses, in that location is a high risk for acetaminophen to be overdosed (more than 4g daily), and this tin cause potentially fatal, hepatic necrosis.

Some NyQuil and Robitussin products tin can comprise pseudoephedrine and phenylephrine as active ingredients, and their potential interaction can amplify sympathetic (adrenergic) effects, including increased claret pressure and heart charge per unit. Patients with cardiovascular diseases and patients with a history of middle attacks shouldn't utilise these medicines.

NyQuil and Robitussins preparations usually contain antihistamines with hypnotic effects such as: doxylamine, diphenhydramine, promethazine or chlorpheniramine, and then their combination may increase sedation and drowsiness.

A significant interaction that can cause cardiac arrhythmias or sudden expiry may occur after mixing NyQuil D that contains nasal decongestive pseudoephedrine and Robitussin formulations with antihistamine promethazine. All the same, this interaction is more likely to happen simply in certain predisposed patients.

The table below shows the incidence of side furnishings afterwards NyQuil and Robitussin administration in recommendable doses. This Incidence can exist significantly increased if these drugs are taken together.

Incidence	Side furnishings
Frequency Not Defined	Hypertension, Tachycardia, Hypotension, Reflex tachycardia, Astringent peripheral and visceral vasoconstriction, Tremor, Dizziness, Excitability, Headache, Sedation, Sleepiness, Restlessness, Dermatologic rash, Increased appetite, Xerostomia, Anemia blood dyscrasias (neutropenia, pancytopenia, leukopenia), Bilirubin and alkaline phosphatase may increase, Urinary retention

Special precautions and warnings during NyQuil and Robitussin assistants:

• Patients shouldn't apply these medicines if they have used MAO inhibitors drugs such as furazolidone (Furoxone), phenelzine (Nardil), isocarboxazid (Marplan), selegiline (Eldepryl, Emsam, Zelapar), rasagiline (Azilect), or tranylcypromine (Parnate) in the terminal xiv days. Drug interactions can occur leading to serious side furnishings.
• Significant patients shouldn't use these medications without medical advice; it is non known whether chlorpheniramine, pseudoephedrine or dextromethorphan volition harm an unborn baby. Chlorpheniramine, dextromethorphan, and pseudoephedrine may pass into breast milk and may harm a nursing babe. These medicines should non be used if mother is breast-feeding a baby.
• Patients with phenylketonuria should avoid these medicines.
• Children younger than 4 years should also avert these medicines. These medicines shouldn't be taken for longer than 7 days in a row.
• These medications may impair your thinking or reactions and cause blurred vision. Patients should be conscientious if they drive or practise annihilation that requires being alert and able to meet clearly.
• Patients should avoid alcohol while using these medications. Drinking alcohol tin increase certain side furnishings of these medications.
• Patients should avoid condign dehydrated or overheated during exercises. Chlorpheniramine tin decrease sweating and patients could go more prone to heat stroke
• Patients should avoid these medications if they as well take caffeine pills, diet pills, or other stimulants. Taking decongestants (pseudoefedrine, phenylephrine) together with stimulants tin can increase the risk of unpleasant side effects.
• Medicines such as sedatives, sleeping pills, narcotic pain medicines, medicine for seizures, anxiety or depression, and musculus relaxers can add sedation and sleepiness that can exist too caused past dextromethorphan, chlorpheniramine, promethazine, doxylamine and pseudoefedrine.

Informations retrieved from:

http://world wide web.drugs.com/cdi/nyquil-liquid.html

http://www.webmd.com/drugs/ii/drug-6104/nyquil-oral/details

http://vicks.com/en-united states/scan-products/nyquil

http://www.drugs.com/cdi/robitussin-dm-elixir.html

http://www.webmd.com/drugs/2/drug-151968/robitussin-oral/details

http://www.robitussin.com/robitussin-product-line

http://reference.medscape.com/drug/childrens-robitussin-cough-cold-long-acting-chlorpheniramine-dextromethorphan-999616

http://reference.medscape.com/drug/vicks-nyquil-d-acetaminophen-doxylamine-dextromethorphan-pseudoephedrine-999380#10

http://www.emedicinehealth.com/drug-chlorpheniramine_dextromethorphan_and_pseudoephedrine/page2_em.htm

http://www.drugs.com/mtm/nyquil-cough.html

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